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Microfluidic, CMOS Microelectrode Array-based Organ-on-chip System: a Platform for Personalized Medicine

NOV
14
2019
14. NOV 2019

Presentation Halle B2 SEMICON EUROPA > SMART MedTech > Pioneering Research in Medical Technologies

13:45-14:05 Uhr | Halle B2 Inspiration Hub, Booth B2.261

Themen: SEMICON EUROPA

Sprecher: PhD Thomas Pauwelyn (imec, Life Science Technologies)

Chairman: Anne Van den Bosch (, imec, imec)

Format: Presentation

Sprache: Englisch

Healthcare has traditionally focused on one-size fits-all medication to treat populations instead of tailoring treatments to individual patients. Recent advances in stem cell technology, allow researchers to create models of diseases or individual patients for personalized medicine. Although organ-on-chip devices expose these models to a more physiological cellular environment, these devices face significant challenges including assay throughput, signal quality, and scalability of production.To address these challenges, imec developed a 16k CMOS-based microelectrode array with 16 independent, microfluidic chambers. This platform offers both scalability in fabrication and assay throughput. Further micropatterning of the surface allows for a structured growth that better resembles a specific organ. By combining these devices with patient-specific cell models, these platform shows great potential for cardiac, neuronal, and oncological applications in the field of personalized medicine.

PhD Thomas Pauwelyn

has studied at KU Leuven, Belgium, since 2008. He earned his BSc in Bioscience Engineering specializing in Catalytic Technologies in 2011 and a Master’s inNanoscience and Nanotechnology with the Bioscience Engineering option in 2013. He then received an IWT fellowship to do a PhD at KU Leuven and imec’s Life Science Technologies group, which finished in 2018.Thomas is currently working as a post-doctoral researcher with an Innovation Mandate grant from VLAIO, investigating strategies to valorize the results from his research. Thomas’s research focuses on developing novel organ-on-chip systems for predictive toxicology and drug development. He is also investigating how organ-on-chip devices may help stratify patients and help enable personalized medicine.

PhD Thomas Pauwelyn

imec, Life Science Technologies

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PhD Thomas Pauwelyn

has studied at KU Leuven, Belgium, since 2008. He earned his BSc in Bioscience Engineering specializing in Catalytic Technologies in 2011 and a Master’s inNanoscience and Nanotechnology with the Bioscience Engineering option in 2013. He then received an IWT fellowship to do a PhD at KU Leuven and imec’s Life Science Technologies group, which finished in 2018.Thomas is currently working as a post-doctoral researcher with an Innovation Mandate grant from VLAIO, investigating strategies to valorize the results from his research. Thomas’s research focuses on developing novel organ-on-chip systems for predictive toxicology and drug development. He is also investigating how organ-on-chip devices may help stratify patients and help enable personalized medicine.

PhD Thomas Pauwelyn
Postdoctoral Researcher

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