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The Clinician’s Point of View

NOV
14
2019
14. NOV 2019

Presentation Halle B2 SEMICON EUROPA > SMART MedTech > The Digital Patient: The Future of Artificial Organs & Human Avatars

11:20-11:45 Uhr | Halle B2 Inspiration Hub, Booth B2.261

Themen: SEMICON EUROPA

Sprecher: Prof. Anthony Mathur (Barts Heart Centre & Queen Mary University of London)

Chairman: Patrick Boisseau (Director EU R&I Partnerships Policies, MedTech Europe)

Format: Presentation

Sprache: Englisch

Artificial Intelligence and Virtual Reality are already relied upon by clinicians in interventional cardiology. 3D printing, simulated therapeutic results, anatomical and physiological models, computer generated reconstructions and augmented reality are all part and parcel of a clinician’s daily life. However, our current overarching approach to cardiovascular disease involves silos of care based on prevention, diagnosis, treatment and rehabilitation. There are few tools that allow a holistic, individually tailored approach to these segments. Consortia have a wealth of healthcare data which target these important areas in isolation, rather than linking them across the interactions of a human lifetime. Further, the available data regarding intervention, whether it is prevention, treatment or recovery, is difficult to tailor to the individual in the absence of bespoke sensing technologies linked to proven algorithms. Therefore, there is a pressing demand to amalgamate our data, unify our latest (and future) scientific and engineering research, and apply it to personalised healthcare. We can break the cycle of only reacting to the patient’s heart condition at the point of discovery (cardiac event) by unifying innovative clinical and computational understandings of cardiovascular diseases to develop integrated tools to reveal potential disease pathway years in advance. These unified digital solutions can then be used to guide the actions of the individual, alongside the professional, to manage heart health in radically new pathways. The individual is empowered to identify their risk, recognise their lifestyle challenges, and receive the focussed interventions they need. Our proposal is that human avatars will become Digital Twins – heralding pioneering computational and technological vehicles which wholly represent the human individual and their cardiovascular status, be it in the prediction, prevention, diagnosis, treatment or rehabilitation of cardiovascular disease.

Prof. Anthony Mathur

Anthony Mathur has been a Professor of Cardiology at QMUL & Barts Health Trust since 2009, and leads their Centre for Cardiovascular Medicine and Device Innovation. He is also the Director for Interventional Cardiology and the Head of Interventional Cardiac R&D at Barts Health. Further, he is an adjunct Professor for the Department of Medicine, Yale. Anthony has also sat on several international advisory boards, including chairing the ESC Task Force for stem cells in cardiovascular disease, as well as advising the UK Department of Trade and Industry and the House of Lords Select Committee on cell therapy. Alongside these positions, he regularly reviews papers submitted to Circulation, Heart, the Lancet, and Thrombosis and Haemostasis.Anthony specialises in interventional cardiology and the management of heart failure patients who have failed conventional therapy. He aims to develop new techniques and devices to treat these patients who fall outside the remit of current recognised therapies. His research interests primarily concern the role of stem cells in the treatment of cardiovascular disease and, to date, his research has received over £25m in funding. Of this, £15m was for translational research. Several of his programmes have international recognition, including an adult heart stem cell research programme, and a novel stent development programme. Moreover, he leads a collaborative group with Prof. John Martin (UCL) seeking to address the role of stem cells in the treatment of cardiovascular disease. This partnership has led to the establishment of a large series of clinical trials translating the interesting results produced by basic experimentation, into relevant therapeutic approaches in man. Anthony is currently the CI for one of the first Phase III trials of cell therapy in acute myocardial infarction. Alongside this, he is a Trustee of the Heart Cells Foundation Charity and heads their pioneering Compassionate Treatment Unit for Heart Failure. This dedicated stem cell programme is the UK’s only centre to treat compassionate heart failure patients with their own stem cells.Anthony is also interested in the use of advanced cardiac imaging, particularly in examining the mechanistic aspects of translational research, and was Barts’ Lead Clinician for Advanced Cardiac Imaging. He chairs a joint imaging board, linking Barts’ radiology and cardiology departments, which has assembled a state of the art collection of advanced imaging hardware composed of: cardiac MR, PET/CT, cardiac CT, nuclear perfusion and advanced echo.Within the Centre for Cardiovascular Medicine and Device Innovation, and as part of an on-going collaboration with Yale University, Anthony raised £6m in EU grant funding to create a Cardiovascular Devices Hub. The Hub supports collaborations between academic, clinical and industrial innovators to develop clinically and commercially viable cardiovascular devices. This novel, cross-specialty unit helps SMEs over the hurdles involved in taking new innovations to human trials, thereby catalysing innovation.

Prof. Anthony Mathur

Barts Heart Centre & Queen Mary University of London

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Prof. Anthony Mathur

Anthony Mathur has been a Professor of Cardiology at QMUL & Barts Health Trust since 2009, and leads their Centre for Cardiovascular Medicine and Device Innovation. He is also the Director for Interventional Cardiology and the Head of Interventional Cardiac R&D at Barts Health. Further, he is an adjunct Professor for the Department of Medicine, Yale. Anthony has also sat on several international advisory boards, including chairing the ESC Task Force for stem cells in cardiovascular disease, as well as advising the UK Department of Trade and Industry and the House of Lords Select Committee on cell therapy. Alongside these positions, he regularly reviews papers submitted to Circulation, Heart, the Lancet, and Thrombosis and Haemostasis.Anthony specialises in interventional cardiology and the management of heart failure patients who have failed conventional therapy. He aims to develop new techniques and devices to treat these patients who fall outside the remit of current recognised therapies. His research interests primarily concern the role of stem cells in the treatment of cardiovascular disease and, to date, his research has received over £25m in funding. Of this, £15m was for translational research. Several of his programmes have international recognition, including an adult heart stem cell research programme, and a novel stent development programme. Moreover, he leads a collaborative group with Prof. John Martin (UCL) seeking to address the role of stem cells in the treatment of cardiovascular disease. This partnership has led to the establishment of a large series of clinical trials translating the interesting results produced by basic experimentation, into relevant therapeutic approaches in man. Anthony is currently the CI for one of the first Phase III trials of cell therapy in acute myocardial infarction. Alongside this, he is a Trustee of the Heart Cells Foundation Charity and heads their pioneering Compassionate Treatment Unit for Heart Failure. This dedicated stem cell programme is the UK’s only centre to treat compassionate heart failure patients with their own stem cells.Anthony is also interested in the use of advanced cardiac imaging, particularly in examining the mechanistic aspects of translational research, and was Barts’ Lead Clinician for Advanced Cardiac Imaging. He chairs a joint imaging board, linking Barts’ radiology and cardiology departments, which has assembled a state of the art collection of advanced imaging hardware composed of: cardiac MR, PET/CT, cardiac CT, nuclear perfusion and advanced echo.Within the Centre for Cardiovascular Medicine and Device Innovation, and as part of an on-going collaboration with Yale University, Anthony raised £6m in EU grant funding to create a Cardiovascular Devices Hub. The Hub supports collaborations between academic, clinical and industrial innovators to develop clinically and commercially viable cardiovascular devices. This novel, cross-specialty unit helps SMEs over the hurdles involved in taking new innovations to human trials, thereby catalysing innovation.

Prof. Anthony Mathur
Director of Interventional Cardiology, Bart's Heart Centre

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